Transient neutropenia induced by transfusion of blood exposed to nylon fiber filters

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Transient neutropenia induced by transfusion of blood exposed to nylon fiber filters.

During the course of granulocyte collection by continuous-flow filtration leukopheresis, an abrupt fall in neutrophil count was noted (mean decrease 77%, range 64%-95%). Neutropenia occurred within 5 min of return of blood exposed to the nylon fiber filters and lasted less than 30 min. Saline exposed to the fibers, withdrawal and reinfusion of whole blood, and heparin did not cause neutropenia....

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Nylon-fiber-induced neutrophil fragmentation.

We have investigated the effects of mechanical elution of neutrophils from nylon-wool fiber (NWF) using the scanning electron microscope and biochemical analysis of elution fractions. We have determined that mechanical removal of neutrophils from nylon-wool fiber disrupts neutrophils adherent to nylon-wool fiber and augments release of granules, release of peripheral cytoplasmic fragments, and ...

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induced malaria caused by blood transfusion

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Nylon Fiber Leukapheresis : Associated Complement

The possible role of complement activation in the development of transient granulocytopenia during nylon fiber filtration leukapheresis ( FL) was studied in five normal donors. No changes in hemolytic complement (CH50) titers were observed in the donors’ circulating plasma at any point in the procedure. However, comparison of preand postfilter blood samples drawn 1 mm after donor blood passed t...

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Comparative adherence of granulocytes to endothelial monolayers and nylon fiber.

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ژورنال

عنوان ژورنال: Blood

سال: 1975

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v45.1.141.141